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KMID : 0361720130240040244
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Korean Journal of perinatology
2013 Volume.24 No. 4 p.244 ~ p.250
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Hypoalbuminemia in Extremely Low Birth Weight Infants
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Shon Hyo-Jung
Gwon Myoung-hoon
Lee Jang-Hoon
Park Moon-Sung
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Abstract
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Purpose: We investigated the incidence and clinical course of hypoalbuminemia and identified relevance of prognosis including mortality in extremely low birth weight infants (ELBWIs). Also, we assessed the efficacy of intravenous albumin infusion.
Methods: A retrospective study including 83 preterm infants <1,000 g of birth weight who were admitted to Ajou university hospital`s neonatal intensive care unit from January 2008 to December 2012 was performed. Patients were divided into the normoalbuminemia (≥2.5 g/dL serum albumin, n=42) group and the hypoalbuminemia (<2.5 g/dL serum albumin, n=41) group, and also the hypoalbuminemia group were subdividedinto the intravenousalbumin infusion group (n=36) and the control group (n=5).
Results: Of those 83 ELBWIs, 41 infants (49.4%) were classified as the hypoalbuminemia group. Associated conditions with hypoalbuminemia were patent ductus arteriosus (PDA, 19.5%), intraventricular hemorrhage(IVH, ≥grade III, 4.9%), necrotizing enterocolitis (NEC, ≥stage IIa, 46.3%), pneumonia (4.9%), sepsis (24.4%). Inunivariate analysis, there were no statistically significant differences in major morbidities such as PDA, IVH, NEC, bronchopulmonary dysplasia and mortality between the normoalbuminemia and the hypoalbuminemia groups except gestational age (26+6±2+1 vs. 26+0±1+5, P =0.045) and birth weight (868±117 vs. 783±121,P =0.002). In multivariate logistic regression, birth weight is the only meaningful factor associated with hypoalbuminemia(OR .995, 95% CI .990-.999, P =0.019). The mortality (47.2% vs. 0%, P =0.065) and morbidities did not differ between the intravenous albumin infusion and the control group.
Conclusion: In ELBWIs, there were no significant differences in major morbidities and mortality between thehypoalbuminemia and the normoalbuminemia groups. The lower birth weight is the only factor associated with hypoalbuminemia. In addition, major morbidities and mortality rate were not affected by the albumin infusion.
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KEYWORD
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Hypoalbuminemia, Albumin, Extremely low birth weight infants
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